OMPOSITION
Doxycure 50% Powder for Oral Solution is a yellow - pale yellow colored fine powder. Each g contains 500 mg of doxycycline hyclate.
INDICATIONS FOR USE
It is used in the treatment of digestive and respiratory system infections caused by the sensitive bacteria given below.
Pre-ruminant Calf:
- Bronchopneumonia and Pleuropneumonia arising from
Pasteurella spp
., Streptococcus spp.,
Arcanobacterium pyogenes,
Histophilus somni and
Mycoplasma spp
.
Chicken:
- Respiratory system infections arising from
Mycoplasma spp
., Escherichia coli, Haemophilus paragallinarum, Bordetella avium
- Digestive system infections arising from
Clostridium perfringens and
Clostridium colinum
- Reduction of respiratory tract lesions and morbidity by
Ornithobacterium rhinotracheale
Turkey:
- Respiratory system infections arising from
Mycoplasma gallisepticum
ADMINISTRATION ROUTES AND AMOUNTS
It is applied by mixing with milk replacer food and/or drinking water.
Calf: 10 mg doxycycline hyclat/kg body weight/day dose (20 mg product/kg body weight/day) is administered for 3-5 days, divided into two daily doses.
Chicken: 25 mg doxycycline hyclat/kg body weight/day (50 mg product/kg body weight/day) is administered for 3-5 days.
Turkey: 29 mg doxycycline hyclat/kg body weight/day (58 mg product/kg body weight/day) is administered for 3-5 days.
In application with drinking water, the practical dose can be calculated according to the formula below;
| ….mg product/kg bw/day |
x |
Mean bw of the animals to be treated (kg) |
= The amount of the product to be added to each liter of drinking water |
| Mean daily water consumption (litre) per animal |
To ensure a correct dosage, bodyweight should be determined as accurately as possible to avoid underdosing. The uptake of medicated water depends on the clinical conditions of the birds and the concentration of doxycycline should be adjusted accordingly.
Use appropriately and properly calibrated dosing equipment. The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water should be freshly prepared every 24 hours.
It is recommended to prepare a concentrated presolution and to dilute this further to therapeutic concentrations if required.
It should be ensured that all animals considered for treatment have easy access to medicated water sources. Irrigation equipment should be adequately cleaned after treatment to avoid sub-therapeutic doses of the product. During the treatment, medicated water should be the only source of water for the animals. Medicated water should not be prepared or stored in metal containers, and rusted equipment should not be used. The solubility depends on the pH, and precipitation may occur in drinking water with high alkaline properties.
WITHDRAWAL PERIOD(S)
Chickens, turkeys and calf should not be slaughtered for human consumption during the treatment and respectively for 5, 12 and 7 days following the last treatment.
It should not be used in laying hens. It should not be used in cattle which producing milk for human consumption. It should not be used in laying hens 4 weeks before the start of the laying period.
MARKETING PACKAGING
Sold as 100 g aluminum foil bags, 500 g and 1 kg white polyethylene containers without boxes.
